产品货号：
GS4696
中文名称：
重组小鼠IFN-λ3/IL-28B
英文名称：
Recombinant Murine Interferon-lambda 3/Interleukin-28B
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 19.6kDa,a single non-glycosylated polypeptide chain containing 174 amino acids.
储存条件：冷冻（-20℃）
概述
Murine IFN-lambda 2(IL-28A),IFN-lambda 3(IL-28B)are class II cytokine receptor ligands that are distantly related to members of the IL-10 family(11 - 13%amino acid sequence identity)and type I IFN family(15 - 19%a.a.sequence identity).These cytokines exert bioactivities that overlap those of type I IFNs,including antiviral activity and up-regulation of MHC class I antigen expression.The proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor beta(IL-10 R beta)and a novel IL-28 receptor alpha(IL-28 R alpha,also known as IFN-lambda R1).Murine IL-28B shares 63%,63%,and 52%a.a.identity with human IL-28A,IL-28B,and IL-29,respectively.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组小鼠IFN-λ3/IL-28B，IFN-λ3/IL-28B, Murine
储存条件：冷冻（-20℃）
概述
Murine IFN-lambda 2(IL-28A),IFN-lambda 3(IL-28B)are class II cytokine receptor ligands that are distantly related to members of the IL-10 family(11 - 13%amino acid sequence identity)and type I IFN family(15 - 19%a.a.sequence identity).These cytokines exert bioactivities that overlap those of type I IFNs,including antiviral activity and up-regulation of MHC class I antigen expression.The proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor beta(IL-10 R beta)and a novel IL-28 receptor alpha(IL-28 R alpha,also known as IFN-lambda R1).Murine IL-28B shares 63%,63%,and 52%a.a.identity with human IL-28A,IL-28B,and IL-29,respectively.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞98%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by an anti-viral assay using human HepG2 cells infected with encephalomyocarditis is less than 30ng/ml,corresponding to a specific activity of>3.3×104 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rMuIFN-λ3/IL-28B as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | DPVPRATRLP VEAKDCHIAQ FKSLSPKELQ AFKKAKGAIE KRLLEKDMRC SSHLISRAWD LKQLQVQERP KALQAEVALT LKVWENINDS ALTTILGQPL HTLSHIHSQL QTCTQLQATA EPKPPSRRLS RWLHRLQEAQ SKETPGCLED SVTSNLFQLL LRDLKCVASG DQCV |
相关搜索：重组小鼠IFN-λ3/IL-28B，IFN-λ3/IL-28B, Murine